Investigating Radiation Response After High-Dose Radiotherapy in Patients With Cancers of the Lung

Grant number: 1038399 | Funding period: 2012 - 2014

Completed

Abstract

Radiotherapy is a potentially curative treatment for cancers of the lung. To improve outcomes, modern research efforts have focussed on radiotherapy dose escalation. However a major limitation to dose escalation is the associated toxicity to the lung. At present, the mechanisms of lung toxicity are incompletely understood. This research will investigate biomarkers of radiation response in patients receiving high-dose radiotherapy to the lung by using state-of-the-art scanning techniques.

Related publications (13)

Scholarly works icon

Automated assessment of functional lung imaging with 68Ga-ventilation/perfusion PET/CT using iterative histogram analysis

L McIntosh, P Jackson, N Hardcastle, M Bressel, T Kron, JW Callahan, D Steinfort, N Bucknell, MS Hofman, S Siva

2021-12-01

Purpose: Functional lung mapping from Ga<sup>68</sup>-ventilation/perfusion (V/Q) PET/CT, which has been shown to correlate with p..

Scholarly works icon

PET-detected pneumonitis following curative-intent chemoradiation in non-small cell lung cancer (NSCLC): recognizing patterns and assessing the impact on the predictive ability of FDG-PET/CT response assessment

A Iravani, GA Turgeon, T Akhurst, JW Callahan, M Bressel, SJ Everitt, S Siva, MS Hofman, RJ Hicks, DL Ball, MP Mac Manus

2019-08-01

Purpose: Inflammatory FDG uptake in the lung (PET-pneumonitis) following curative-intent radiotherapy (RT)/chemo-RT (CRT) in non-s..

Scholarly works icon

Automatic delineation of functional lung volumes with 68Ga-ventilation/perfusion PET/CT

PY Le Roux, S Siva, J Callahan, Y Claudic, D Bourhis, DP Steinfort, RJ Hicks, MS Hofman

2017-01-01

Background: Functional volumes computed from <sup>68</sup>Ga-ventilation/perfusion (V/Q) PET/CT, which we have shown to correlate ..

Scholarly works icon

Radiotherapy for non-small cell lung cancer induces DNA damage response in both irradiated and out-of-field normal tissues

S Siva, P Lobachevsky, MP MacManus, T Kron, A Möller, RJ Lobb, J Ventura, N Best, J Smith, D Ball, OA Martin

2016-10-01

Purpose: To study the response of irradiated and out-of-field normal tissues during localized curative intent radiotherapy. Experi..

Scholarly works icon

Respiratory-gated (4D) FDG-PET detects tumour and normal lung response after stereotactic radiotherapy for pulmonary metastases

S Siva, JW Callahan, T Kron, B Chesson, SA Barnett, MP MacManus, RJ Hicks, DL Ball

2015-09-14

Background. Response assessment after stereotactic ablative body radiotherapy (SABR) in lung can be confounded by radiation-induce..

Scholarly works icon

Accuracy and utility of deformable image registration in 68Ga 4D PET/CT assessment of pulmonary perfusion changes during and after lung radiation therapy

N Hardcastle, MS Hofman, RJ Hicks, J Callahan, T Kron, MP MacManus, DL Ball, P Jackson, S Siva

2015-09-01

Purpose Measuring changes in lung perfusion resulting from radiation therapy dose requires registration of the functional imaging ..

Scholarly works icon

Dosimetric consequences of 3D versus 4D PET/CT for target delineation of lung stereotactic radiotherapy

S Siva, B Chesson, JW Callahan, N Hardcastle, L Crawford, P Antippa, G Wright, MP Macmanus, RJ Hicks, T Kron, DL Ball

2015-07-04

Introduction: Lung tumor delineation is frequently performed using 3D positron emission tomography (PET)/computed tomography (CT),..

Scholarly works icon

Comparison of Single-fraction and Multi-fraction Stereotactic Radiotherapy for Patients with 18F-fluorodeoxyglucose Positron Emission Tomography-staged Pulmonary Oligometastases

S Siva, K Kirby, H Caine, D Pham, T Kron, L Te Marvelde, D Whalley, MJ Stevens, F Foroudi, M MacManus, D Ball, T Eade

2015-06-01

Aim: To compare outcomes of single-fraction and multi-fraction stereotactic ablative body radiotherapy (SABR) for pulmonary metast..

Scholarly works icon

High-resolution pulmonary ventilation and perfusion PET/CT allows for functionally adapted intensity modulated radiotherapy in lung cancer

S Siva, R Thomas, J Callahan, N Hardcastle, D Pham, T Kron, RJ Hicks, MP MacManus, DL Ball, MS Hofman

2015-05-01

Background and purpose: To assess the utility of functional lung avoidance using IMRT informed by four-dimensional (4D) ventilatio..

Scholarly works icon

CT perfusion imaging in response assessment of pulmonary metastases undergoing stereotactic ablative radiotherapy

B Sawyer, E Pun, M Samuel, H Tay, T Kron, M Bressel, D Ball, S Siva

2015-04-01

Introduction Stereotactic ablative body radiotherapy (SABR) is an emerging treatment technique for pulmonary metastases in which c..

Scholarly works icon

Abscopal effects of radiation therapy: A clinical review for the radiobiologist

S Siva, MP MacManus, RF Martin, OA Martin

2015-01-01

An "abscopal" effect occurs when localized irradiation perturbs the organism as a whole, with consequences that can be either bene..

Scholarly works icon

A pattern of early radiation-induced inflammatory cytokine expression is associated with lung toxicity in patients with non-small cell lung cancer

S Siva, M MacManus, T Kron, N Best, J Smith, P Lobachevsky, D Ball, O Martin

2014-10-07

Purpose: Lung inflammation leading to pulmonary toxicity after radiotherapy (RT) can occur in patients with non-small cell lung ca..

Scholarly works icon

A prospective observational study of Gallium-68 ventilation and perfusion PET/CT during and after radiotherapy in patients with non-small cell lung cancer

S Siva, J Callahan, T Kron, OA Martin, MP MacManus, DL Ball, RJ Hicks, MS Hofman

2014-10-02

Background: Non-small cell lung cancer (NSCLC) accounts for 85% of lung cancers, and is the leading cause of cancer deaths. Radiat..

University of Melbourne Researchers